Oncogene Products v erbA

《英文msh詞典》Oncogene Products v erbA
[入口詞] Oncogene Products v erbA
[主題詞] Oncogene Proteins v-erbA
[英文釋義] Transforming proteins encoded by erbA oncogenes from the avian erythroblastosis virus. They are truncated versions of c-erbA,the thyroid hormone receptor (RECEPTORS,THYROID HORMONE) that have retained both the DNA-binding and hormone-binding domains. Mutations in the hormone-binding domains abolish the transcriptional activation function. v-erbA acts as a dominant repressor of c-erbA,inducing transformation by disinhibiting proliferation.